Interleukin-18 produced by bone marrow derived stromal cells supports T cell acute leukemia progression
نویسندگان
چکیده
You find that inhibition of MEK promoted growth of xenografted or human primary leukemic cells in co-culture with stromal cells and that inhibition of MEK specifically in stromal cells promoted TALL cell proliferation. You also find IL-18 as major secreted factor and confirm that T-ALL cells have IL-18 receptors and a portion of samples are stimulated by IL-18, possibly via NFkB. We appreciate that an IL-18 blocking body decreased T-ALL growth in xenografted mice and that IL-18 levels were increased both in xenografted mice and in patients. Finally, you observed a better outcome for low IL-18 in a specific clinical subset.
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تاریخ انتشار 2014